https://www.menonlab.org/lab-alumni daily 0.75 2024-11-11 https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587838988433-XQCF1Y277NCWW9PJACRC/lab+alumni+gallery-1.png Lab Alumni Niki Baumann, Bill Watkins, Christian Frank, Anita Pottekat, Dave Rancour, Yves Sere https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587849489796-7RO6SVRICINA32IBPF4J/lab+alumni+gallery-3.png Lab Alumni Jolanta Vidugiriene, Kiran Andra, Aita Signorell, Mike Goren, Rabia Iqbal, Julian Jentsch https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587754616904-SVK1J1WYCGGXTCQK3YDN/Birgit-Neha+2016.JPG Lab Alumni - Birgit Ploier & Neha Chauhan Birgit Ploier and Neha Chauhan https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587844960554-JTCWRECJ4NB86OYUK9RX/lab+alumni+gallery-2.png Lab Alumni Leroy Pakkiri, Alice Verchère, Ashley Brown, Saulius Vainauskas, Sigrún Hrafnsdóttir, Daphne Bindels https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587755180659-567GPX14ENMCMDDAAG42/Dave-Henna.gif Lab Alumni Dave Sullivan and Henna Ohvo-Rekilä https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/4c324d45-674e-4190-afba-b721c5aeb874/20230210+Helene+Jahn+PhD+defense.jpeg Lab Alumni - Make it stand out Helene Jahn (right), after her PhD defense (February 2023) https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587849576267-HHKHNLWS8G72G0DZZFA1/lab+alumni+gallery-4.png Lab Alumni Madhavan Chalat, Mike Kersting, Sumana Sanyal, Alexander Georgiev, Kalpana Pandey, Sathya Gummadi https://www.menonlab.org/lab-members daily 0.75 2026-01-21 https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/b20f0bbe-cd45-4467-ba4d-3a96aecc7151/AKM+May2022.jpg Lab Members - Anant K Menon Professor M.Sc. (1980) Indian Institute of Technology, Kanpur (with Prof. N. Sathyamurthy) Ph.D. (1986) Cornell University (with Prof. Barbara Baird) Postdoctoral Associate (1986-1989) The Rockefeller University (with Prof. George Cross) Previous faculty positions at The Rockefeller University (1989-1993) and the University of Wisconsin-Madison (1993-2005) akm2003@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/44b47d70-af06-4f99-8d42-2c8acaed564b/IMG_7510.jpg Lab Members - Ken-taro Sakata Postdoctoral Associate B.S. (2018) Kagawa University, Kagawa. M.S. (2020) Kagawa University, Kagawa Ph.D. (2023) Ehime University, Kagawa kes4026@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/09688225-66c2-40c3-a6a2-9333f47d792c/Faria+Noor+8Apr24.jpeg Lab Members - Faria Noor Research Technician B.A. (2023) Hunter College, New York fan4006@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/bee63dcd-a31e-446b-9aca-cb5ecad25813/Indu-Yeeun.jpg Lab Members - Indu Menon Senior Staff Associate M.S. (Microbiology) Columbia University, New York M.S. (Epidemiology) University of Wisconsin-Madison inm2001@med.cornell.edu (photo with BCMB rotation student Yeeun Son) https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/2eeac80c-d486-4f57-894f-ad0f98a939d9/HMM02545.jpg Lab Members - Haodong Wang Postdoctoral Associate B.S (2018) Tianjin University, China Ph.D (2024) Tsinghua University, China haw4023@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/d0a1da01-f969-410e-b38d-d4b6f3f62a3f/IMG_20241207_001230.jpg Lab Members - Sabita Chourasia Visiting Postdoctoral Associate B.Sc. (2011) Dibrugarh University, India M.Sc. (2014) Lucknow University, India Ph.D. (2024) Weizmann Institute of Science, Israel sabita.chourasia@weizmann.ac.il https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/f4f62923-a4b5-4625-9877-7df1ceb9da70/Lab+pic+edited.jpg Lab Members - Hannah Wolfe Research Technician B.S. (2024) University of Cenral Florida, Florida haw4016@med.cornell.edu https://www.menonlab.org/new-page daily 0.75 2024-11-13 https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587673278620-I0P8VNXVI3SHGG2Y8MMS/Steinberg+detailed.jpg Research - GPCR-mediated lipid scrambling The G protein coupled receptor rhodopsin translocates phospholipids from one side of a membrane bilayer to the other at a unitary rate of >100,000 per second (Menon et al. (2011) Curr Biol (image by Adam Steinberg)). The ‘lipid pathway’ was suggested by molecular dynamics simulations (Morra et al. (2018) Structure). We are testing this pathway experimentally. https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587861346337-N08QONQD8U52FL01FHFO/Ysp2+micrograph.png Research - A sterol-binding protein at ER-PM contact sites Fluorescence image of yeast cells. Lam2/Ysp2 (green) is an ER membrane protein found at contact sites between the ER and plasma membrane (red). We are studying how its sterol binding domain is able to exchange sterols between membranes (Gatta et al. (2015) eLife 4:e07253; Jentsch et. al. (2018) J. Biol. Chem., 293:5522; Khelashvili et al. (2019) eLife 8:e53444) https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1588011274439-TUQ681N90WCY05DC6KAF/MPD+multifunctional+lipid.png Research - Mannose-P- dolichol scramblase Mannosylphosphoryldolichol (MPD) is a multifunctional lipid. It provides mannose residues for glycosyltransfer reactions in the lumen of the ER for protein N-glycosylation, O-mannosylation, W-mannosylation and GPI anchoring. It is synthesized on the cytoplasmic face of the ER and transferred to the ER lumen by MPD scramblase, a protein whose molecular identity is not known. Figure taken from Sanyal, Menon (2010) PNAS 107:11289. https://www.menonlab.org/publications daily 0.75 2024-12-01 https://www.menonlab.org/new-page-2 daily 0.75 2025-11-04 https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/d76d15ee-6c8a-482e-a8f4-b8d4b6474b39/buetikofer.jpg Collaborators - Peter Bütikofer Institute of Biochemistry and Molecular Medicine, Universität Bern https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/ee7e97fe-a4b4-47dd-8b92-d32bb81dfee0/Haener_Robert.jpg Collaborators - Robert Häner Department of Chemistry and Biochemistry, Universität Bern https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1587749167050-9E2PHP2A1TNGNFQCTKBI/George-2016.JPG Collaborators - George Khelashvili Department of Physiology and Biophysics, Weill Cornell Medical College https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/d7c39f00-a162-4f88-80d3-5643029442eb/Kenichi+2019.png Collaborators - Kenichi Morigaki Biosignal Research Center, Kobe University https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/9d935281-2200-4b0b-ba96-3ed1a78a7cd1/robert+vacha.jpg Collaborators - Robert Vacha Central European Institute of Technology, Masaryk University https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/8f4110a1-843e-4ec2-a2c6-e51029c50d4d/David+E+2019.png Collaborators - David Eliezer Department of Biochemistry, Weill Cornell Medical College https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/88925c9e-3a25-4787-b23b-979f245ddfd6/ernst.jpg Collaborators - Oliver Ernst Department of Biochemistry, University of Toronto https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/0fedbf2b-5a57-45e2-ad74-ff5e6e99e6b4/levitz.png Collaborators - Josh Levitz Department of Biochemistry, Weill Cornell Medical College https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/2df7f2e3-8098-4f79-bfb4-6933e29182c0/IMG_9786.jpg Collaborators - Thomas Günther-Pomorski Biochemistry II - Molecular Biochemistry, Ruhr-Universität Bochum https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/59e56406-54f3-4ce2-b88d-31c5a7f37ab3/Johannes-Anna%2B25Jan2018.jpg Collaborators - Johannes Graumann Max Planck Institute for Heart and Lung Research, W.G. Kerckhoff Institute, Bad Nauheim (photo with postdoctoral fellow Anna Magdalena Sokol) https://www.menonlab.org/contact-links daily 0.75 2022-11-02 https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1588007424109-4X7VNXZ4SEKXQ90SY06U/1300+York+Ave+-+Google+Maps+3D.png More ...... https://www.menonlab.org/newscience daily 0.75 2026-01-07 https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/9de23f19-2e70-425e-b7d3-b86c64a557a7/240307_R37A_Image54_GFP.png New Science - Molecular characterization of Rft1, an ER membrane protein associated with congenital disorder of glycosylation RFT1-CDG Hirata, E., Sakata, K., Dearden, G.I., Noor, F., Menon, I., Chiduza, G.N., Menon, A.K. (2024) J. Biol. Chem. https://www.jbc.org/article/S0021-9258(24)02085-4/fulltext https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/f92b9d1b-4d47-498b-8ccc-340f030b5a01/VDAC+top-side+views+scrambling.png New Science - Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase Phospholipid(s) scrambling along the interface of a VDAC dimer (top, top view; bottom, sideview in the membrane). Snapshots from a coarse-grained molecular dynamics simulation. The dimer is shown using molecular surface, the headgroups of most lipids are shown as gray beads and their tails as gray tubes, while transiting lipids are highlighted in orange. Most lipids in front of the dimer are not depicted, except for several phosphate groups that are located close to the dimer. https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/1a590ba9-90e5-44d3-943a-2867a6f42e40/GPCR+choelsterol+threshold.jpg New Science - A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors Menon, I., Sych, T., Son, Y., Morizumi, T., Lee, J., Ernst, O.P., Khelashvili, G., Sezgin, E., Levitz, J., Menon, A.K. (2024) J. Biol. Chem. https://www.jbc.org/article/S0021-9258(24)00025-5/fulltext https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/c1ccdedc-d9b7-4928-9a33-166a631fdab0/structure-cover.jpg New Science - Insertases scramble lipids: Molecular simulations of MTCH2 Bartoš, L., Menon, A.K., Vácha, R. (2024) Structure https://www.cell.com/structure/fulltext/S0969-2126(24)00036-4 https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/9aebbf05-d34b-485c-a784-be506fa9f04d/credit+card+model.jpg New Science - Credit card mechanism of phospholipid scrambling Proposed by Pomorski, Menon (2006) to explain how a membrane protein translocates phospholipids (image by Adam Steinberg). Recent work on GPCR and TMEM16 scramblases supports this model. https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/f82d33f9-cf3f-483d-96b6-0390251d93be/ActR+mBio03278-25_cover.png New Science - Opsins are phospholipid scramblases in all domains of life Maschmann, Z.A., Hardy, D.E., Menon, I., Webb, J., Menon, A.K., Forest, K.T. (2025) mBio https://journals.asm.org/doi/10.1128/mbio.03278-25 Image created by David Hardy, Forest lab, University of Wisconsin-Madison https://www.menonlab.org/home daily 1.0 2025-11-04 https://images.squarespace-cdn.com/content/v1/5c6033c577b903f8f5dcd6e5/69fed2a3-dddd-4eaf-9e45-6b6648ad11fe/fig1+edited.jpg Home - How phospholipids enter mitochondria - a problem of intracellular lipid transport How phospholipids enter mitochondria Schematic showing phospholipid transport from the endoplasmic reticulum (ER) to all bilayer leaflets of the mitochondrial double membrane. Non-vesicular mechanisms deliver ER-synthesized phospholipids to the cytoplasmic face of the outer mitochondrial membrane (OMM). The lipids are scrambled across the OMM by a lipid transporter (scramblase) before moving through the intermembrane space (IMS) and across the inner mitochondrial membrane (IMM). https://www.menonlab.org/vdac-sim daily 0.75 2024-01-18